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Several genes were identified as target genes of Nrf2 following treatment of erastin and sorafenib, including quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO1), and ferritin heavy chain 1 (FTH1), which were involved in ROS and iron metabolism

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These regions are thought to coordinate various homeostatic and motivational behaviors, and the introduction of an agonist like Melanotan 2 may potentially reframe the balance of neuronal activity

On the other hand, insulin does this by inducing direct phosphorylation via Akt (protein kinase B) on serine485 of the 1AMPK subunit, which was showed to inhibit threonine172 phosphorylation and thus promote cell survival and proliferation (158)