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Goals of Treatment Eliminating the entire at risk mucosa Minimizing complications Minimizing recurrence, strictures and bleeding Decreasing the need for frequent surveillance To meet these objectives, the correct depth ablation should target to, but not beyond, the muscularis mucosa

The stress response is a highly dynamic and complex process, whose function is additionally influenced by the age, sex, type, and duration of the stressor and an individual ability to cope with it, known as resilience

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Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

ID 3251212 (ed