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FragodimitriCSchizaVGiakoumisADrakakiKSalichouAKarampatsosFet alSuccessful chelation in Beta-thalassemia major in the 21st century
This effectively inhibited the IL-11 signaling pathway in both hepatocytes and hepatic stellate cells
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For example, in MMTV-PyMT transgenic mice, CSC-like cells rely on autophagy through EGFR/STAT3 and TGF-/Smad pathways for tumorigenesis, whereas in human cancers, FOXO3-mediated transcription of autophagy-related genes (such as ATG5, LC3, Beclin-1) associates autophagy with CSC persistence and resistance to chemotherapy
