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doi: 10.1172/JCI107603 70 BiemondPvan EijkHGSwaakAJKosterJF

The synthetic, delta-9-THC analog, nabilone (12 mg/day administered orally) significantly reduced agitation and improved overall neuropsychiatric symptoms in a group of 39 patients with Alzheimers disease in a randomized, double-blind, crossover trial (6-weeks active treatment, 6-weeks placebo separated by a 1-week washout period)

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Oral dosing keeps plasma ascorbate below roughly 220 micromoles per liter (mol/L), whereas controlled IV infusion can safely **generate** pharmacologic concentrations of 2530 millimoles per liter (mmol/L)a finding documented by Mark Levines National Institutes of Health group in Vitamin C pharmacokinetics: implications for oral and intravenous use (Padayatty and colleagues, Annals of Internal Medicine, 2004)