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For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability

doi: 10.1038/s41598020738404 167 MiyataAArimuraADahlRRMinaminoNUeharaAJiangLet al

If the effectiveness isn't enough, some people simply hate needles

(PubMed) Mares-Perlman JA, Brady WE, Klein BE, et al

Cordycepin in Anticancer research: molecular mechanism of therapeutic effects
