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Mitochondrial mechanisms underlying antidepressant efficacy and future directions Considering that mitochondrial regulation is a key downstream mechanism involved in the pathophysiology of MDD, we summarize how conventional and rapid-acting antidepressants, as well as mitochondria-targeted compounds, modulate bioenergetics, oxidative defense, mitophagy, and neuroinflammatory signaling, and discuss their therapeutic implications and future directions (Fig

In addition, for patients with DM complicated with clear vascular and neuropathy, routine treatment with antioxidants, neurotrophic drugs, and medication to improve microcirculation can be given (7276)

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There is rising participation in sports and fitness activities, creating demand for supplements that provide energy and facilitate muscle recovery

Nat Med (2017) 23(3):27987