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B6 is also a cofactor for the CBS enzyme in the trans-sulphuration pathway which converts homocysteine to cysteine 21 Supplementation with N-acetyl cysteine (NAC) which provides the cysteine substrate has been shown to increase levels 19 The non-essential amino acid, serine may positively influence glutathione production through increased cysteine availability and a decrease of hypermethylation, as well as its metabolism into glycine, one of glutathiones precursors

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Acad Radiol 19:14571464 Allen K, Jaeschke H, Copple BL (2011) Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis

In the placebo group, only 0.7% reported it

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