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C.TurriniF

Real-world use beyond this timeframe is becoming more common, with many individuals maintaining therapy for years

Zhang Z, Cheng J, Yang L, Li X, Hua R, Xu D, et al

These highly expressed metabolic enzymes promote glucose and glutamine metabolism in the PPP and augment the synthesis of purine and amino acids, all of which contribute to metabolic reprogramming for cell proliferation.36 Nrf2 also regulates genes involved in metabolism of fatty acids and other lipids.83 Moreover, microRNA miR1 and miR206 are under control of Nrf2 to direct carbon flux toward PPP and tricarboxylic acid (TCA) cycle.84 Nrf2 promotes cell proliferation not only by metabolic reprogramming

Male Sprague-Dawley rats, weighing 200 to 250 gm, were used as the source of tendon fibroblasts in this study