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The MRSD can be further refined based on the anticipated therapeutic window : the dosage range sitting between the minimum effective concentration (MEC) and the minimum toxic concentration (MTC)

The two peptides use complementary rather than identical mechanisms

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Conversely, the p53 / Rb1 / Rbl2 triple knockout mouse model shares similar features with the p53 / Rb1 double knockout model, and they both reliably recapitulate the ASCL1-high/NEUROD1-low subtype of human SCLC [148]

These washout periods, which have been updated slightly since the 2022 List documents were published on 30 September to incorporate the latest scientific information, are highlighted in the revised version of the Summary of Major Modifications and Explanatory Note, and are based on the use of these medications according to the maximum manufacturers licensed doses
