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Our results did not support this hypothesis since there was no statistical difference among groups of CoQ10 and dihydroorotate dehydrogenase (DHODH) (Supplementary Figures S5AC)

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This is consistent with the finding in rodent SCN that CLOCK shows stable levels during the 24-hour cycle and is constitutively expressed in the mouse SCN ( At the protein level, circadian oscillation of clockwork negative factors such as PERs and CRYs were expected to be in anti-phase with BMAL1, and to be more highly expressed during the dark period relative to the night based on studies on mouse SCN ( Figure 2 )