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424 Another Phase I clinical trial that included 55 patients with advanced malignancies who had failed platinum treatment demonstrated that trientine, administered as a maximum daily divided dose of 3000 mg, can be safely combined with carboplatin FDA-approved doses (AUC 6), showing good tolerance

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2.3.2 Usefulness in autoimmune diseases 2.3.2.1 Rheumatoid arthritis Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a complex and dynamic immunopathogenesis

These cracks can bleed or cause pain, particularly in areas of frequent movement like joints or fingers

Liu C, Zheng L, Wang H et al (2015) The RCAN1 inhibits NF-B and suppresses lymphoma growth in mice