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Disruption of this balance is linked to various pathological conditions, including inflammatory and degenerative diseases (109)
The eCB name is obviously derived from the term cannabis, and this is due to the fact that CB1 is also the primary CNS molecular target for 9 -tetrahydrocannabinol ( 9 THC), the major psychoactive ingredient in preparations of Cannabis sativa , which acts as a partial agonist at these receptors

Accordingly, it is postulated that the high glutamate concentration in the intestinal microenvironment, which may reach the millimolar range, could prevent inappropriate responses to dietary antigens by exerting immunosuppressive effects on intestinal T cells (178)

Moylan S, Berk M, Dean OM, Samuni Y, Williams LJ, ONeil A, et al

This helps to prevent serious complications of diabetes like kidney damage and blindness
