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Notably, all three appear to have a positive action on toning down inflammatory processes

Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies

Translational percentages (concordance rates) of results exhibit a wide range from 0100% with no predictable factors for translational success or failure in humans (309), and even multiple experiments fail to significantly contribute to improving the reproducibility of animal testing, accounting for 41%72% of the observed total variance (310, 311)

doi: 10.1097/00003086-199706000-00034