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The destruction of membrane structure not only directly weakens sperm motility but also severely interferes with the ability of sperm to fuse with the oocyte plasma membrane during fertilization (spermoocyte fusion) (34, 90)

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244 In vascular smooth muscle cells, ROS activate c-Abl, which phosphorylates PKC (Tyr512/523), 245 leading to PYK2 phosphorylation (Tyr402/579) and subsequent JAK2 transphosphorylation