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The following ATPADP transition in the NBD closes the flexible double-hinged lid of the SBD, preventing the client protein from leaving ( HSP70s exert three major activities on client proteins: 1) preventing nascent proteins from misfolding and facilitating their proper folding

Dexamethasone reduces the connective-tissue inflammation that drives fluid leakage, while hydrochlorothiazide increases urine production to remove fluid that has already accumulated, producing a combined anti-oedematous effect

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