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In addition, it has been found that cisplatin is a substrate of CT2
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doi: 10.1093/hmg/7.5.839 141 TrichopoulouA.CostacouT.BamiaC.TrichopoulosD
Furthermore, the expression of the key glycolytic enzyme PFKFB3 is upregulated and mediates increased PD-L1 expression by activating the nuclear factor B signaling pathway, thereby inhibiting the anti-tumor activity of cytotoxic CD8+ T lymphocytes (82)
Salter AM, Fisher SC, Brindley DN: Binding of low-density lipoprotein to monolayer cultures of rat hepatocytes is increased by insulin and decreased by dexamethasone
