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Step 5 For all devices, your Sponsor submits a medical device application

Loss of barrier integrity facilitates translocation of luminal bacteria, endotoxins, dietary antigens, and metabolic waste into the systemic circulation, activating maladaptive immune responses that drive mucosal inflammation

The copper-dopamine-norepinephrine pathway explains much of this excess free copper drives excess norepinephrine, producing the stimulated, reactive state that characterizes the clinical picture

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Again, it depends