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Intended for research purposes only

The industrial activities of the last century have caused massive increases in human exposure to heavy metals

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Glutamate, too, incited platelet spreading and adhesion on to immobilized matrix under arterial shear, raised mitochondrial transmembrane potential associated with generation of reactive oxygen species and induced activation of AMP-activated protein kinase in platelets

Our results provide new insights into the structure of -GCS-GS and suggest -GCS-GS evolved from a monomeric -GCS that became C-terminally fused to a multimeric ATP-grasp protein.