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That holds even for people who would not otherwise have difficulties
considering the brain and the CNS specifically, BBB penetration rates and the P-glycoprotein (P-gp) efflux pump are critical factors limiting their application in the clinic [1]
Cerulenin mimics effects of leptin on metabolic rate, food intake, and body weight independent of the melanocortin system, but unlike leptin, cerulenin fails to block neuroendocrine effects of fasting
[DOI] [PubMed] [Google Scholar] 212.Liu Z, Liu X, Bao L, Liu J, Zhu X, Mo X, et al
