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[58] proposed a metabolic trap hypothesis that suggests ME/CFS patients suffer from insufficient kynurenine production due to gene mutations in IDO2 [58]

(2017) ACS Med Chem Lett 8 : 963-968 PubMed: 28947945 Search on PubMedSearch on PubMed Central DOI: Primary Citation Related Structures: 5ULN, 5UMC, 5WEX PubMed Abstract: A series of benzenesulfonamides bearing selenourea moieties was obtained considering the ureido-sulfonamide SLC-0111 , in Phase I clinical trials as antitumor agent, as a lead molecule

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Based on the aforementioned phase-2 clinical trial results, the compound was included in phase-3 trials which investigated its potential to prevent muscle wasting in patients with advanced lung cancer