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Lim, et al
MOTS-c treatment enhances physical capacity in old mice Aging is accompanied by a progressive decline in mitochondrial function 1,24 and loss of metabolic homeostasis, in which MOTS-c may play a role 2,10
Kozlov AM, Darriba D, Flouri T, Morel B, Stamatakis A

When we started he could walk/run on only three legs
[PMC free article] [PubMed] [Google Scholar] Cornil CA, Balthazart J, Motte P, Massotte L, Seutin V (2002) Dopamine activates noradrenergic receptors in the preoptic area