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Frailty indices include grip strength, gait speed, or other indirect measurements of muscle mass, strength, and function

For the 500-yr simulation, we calculate the DJFM TX10d and JJAS TX90d from daily data in the same way as for the observational data, but here the percentiles are calculated with respect to the full 500-yr period

The amount of water affects the concentration (e.g., mg/mL), but not the total potency of the peptide in the vial

10.1038/mi.2010.31 Mucosal

2-DG also attenuates enhanced mitochondrial respiration and reduces the expression of M2 phenotypic markers, such as Arg1, chitinase-like protein 3 (YM-1), found in inflammatory zone 1 (FIZZ-1), and CD206 (81)