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Instead, macrophages of the M2 phenotype do not have a clear counterpart in the transcriptional subsets, but its protein markers arginase and mannose receptor are found more in the shoulder regions covering the lipid core region and are less prone to develop into foam cells ( The metabolic pathways of glycolysis, the TCA and OXPHOS cycle, the PPP, lipid as well as amino acid metabolism play an important role in macrophage polarization and subsequently their inflammatory phenotype and contribution to atherosclerotic plaques (Koelwyn et al., 2018

Stefano Sinicropi, Founder of HyperCharge Health Disclaimer: This blog is for informational purposes only and does not constitute medical advice