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NNMT activity is known to increase as aging progresses or in response to certain lifestyle factors, often resulting in a decline in metabolic efficiency and a buildup of stubborn fat

Per FDA guidance, GLP-1-based medications are generally approved for adults with a BMI over 30, or over 27 with a qualifying health condition such as type 2 diabetes, high blood pressure, or high cholesterol

Patients on long-term PPIs should have their B12 status monitored periodically, particularly if other risk factors are present

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