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Szabo S, et al
Mann, B
D2KO mice are more vulnerable to ventilator induced lung injury (110), whereas heterozygous D3KO mice are more vulnerable to a chemically induced worsening of restrictive cardiomyopathy, leading to congestive heart failure and increased mortality (155)
It also influences mitochondrial biogenesis by upregulating sirtuins, particularly SIRT1 and SIRT3, which play roles in deacetylating mitochondrial proteins and enhancing complex I activity [1,60]
Molecules 22 (6), 1013