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Deficiency in MCAD is the most common defect observed in the process of mitochondrial -oxidation of fatty acids

Araki M, Nakagawa Y, Oishi A, Han SI, Wang Y, Kumagai K, Ohno H, Mizunoe Y, Iwasaki H, Sekiya M, Matsuzaka T, Shimano H

All synergy data derive from in vitro cell cultures (rat pituitary cells) and in vivo animal studies (rats, dogs, swine)

ICH Q2 (R1), Validation of analytical procedures: text and methodology, in Proceedings of the International Conference on Harmonization, Geneva, Switzerland, 2005

During the aging process, the expression of NRF2dependent antioxidant enzymes decreases, thereby leading to oxidative stress and related diseases [176]