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Our previous study has indicated that ROS-mediated mitochondrial dysfunctions are observed in DMM-induced OA mice [46]

PMID: 18980482 Jabbour, P., Fehlings, M., Vaccaro A.R.., Harrrop, J.S.: Traumatic spine injuries in the geriatric population

These persistent abnormal signals may then lead to lasting epigenetic reprogramming, altering the gene expression of cells through DNA methylation, histone modifications, and non-coding RNA

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Should future research validate its advantages, it may eventually be utilized in conjunction with stem cell therapy, tailored scaffolds, or alternative biomaterials to augment healing [4][3]
