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Furthermore, flavokavains A and B were shown to have immunomodulatory functions, such as the stimulation of splenocyte proliferation and the secretion of IL-2 and TNF- in harvested splenocytes, as well as an increase in the subsets of T cell populations in BALB/c mice, with flavokavain B being more potent than flavokavain A (30 g/mL) [59]

Apart from -synuclein, Lewy bodies also contain many other aggregated cellular proteins, which together constitute an interactome to promote fibrillation of -synuclein ( Under normal physiological conditions -synuclein exists mostly in an N acetylated membrane bound form which results in adoption of an -helical structure (Runfola et al., 2020)

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