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It has been studied specifically for its role in intestinal inflammation, with preclinical research showing it can reduce pro-inflammatory cytokine activity in gut tissue
Those following a vegan diet or with a history of heavy alcohol consumption might need higher B12 supplement dosages

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These informal reports propose a potential daily dosage ranging from 50mg to 150mg

Watson J, Deary I, Kerr D (2002) Central and peripheral effects of sustained caffeine use: tolerance is incomplete
