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Description
Chronic tendinopathies
Some patients may experience a transient increase in acne or rosacea-like skin reactions, thought to be related to the effects of vitamin B12 on skin bacteria, though this is uncommon and typically mild
543 The JAK-STAT pathway serves as a hub for cytokine signaling, and inhibitors such as tofacitinib effectively block IL-6- and IL-23-mediated immune cell activation by competitively occupying the ATP binding site of the kinase
However, most of this research has been conducted in animal models, and human safety and efficacy data are limited
No washout period is required
