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Reactions involved in transport and lipid metabolism were under-represented in chloroquine treated models ( p -value = 0.0061 and 2.51E-8, respectively)

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Likewise, SAMP8 mice, which are used as a model for Alzheimers disease, show increased formaldehyde-producing semicarbazide-sensitive amine oxidase (SSAO) and decreased ADH5 activity in the brain [31]

Acta Biochim Biophys Sin (Shanghai) 2014;46:10411048