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10.1038/cr.2016.100 28 ChenY.FangZ.-M.YiX.WeiX.JiangD.-S

What If the Injection Site Swells or Forms a Lump

developed a dual-target ADC for EpCAM and CLDN3, which requires high co-expression of both antigens on tumors for effective killing, exhibiting minimal toxicity to normal cells that only highly express EpCAM but have low CLDN3 levels, thereby alleviating the toxicity limitations of single-target EpCAM ADCs [138]