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Dysfunctional TJs have been discovered in coeliac patients and potentially contributes to intestinal leakage providing an access route for gliadin to the underlying immune system in the lamina propria (Schulzke et al

But "smaller" doesn't mean insignificant

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These studies show that people with higher levels of vitamin D have a lower risk of disease, although they do not definitively prove that lack of vitamin D causes disease or that vitamin D supplements would lower risk