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To this end, various structureactivity relationship (SAR) methodologies are employed, including, but not limited to, site-directed mutagenesis, rational computational design, high-throughput screening of synthetic peptide libraries, template-guided structural refinement, and mechanism-driven design strategies inspired by natural biological processes

[DOI] [PMC free article] [PubMed] 4.Klop B, Elte JWF, Cabezas MC

Moreover, reduced sirtuin (class III HDAC) activity has been observed in Menieres disease, a disorder frequently accompanied by tinnitus, correlating with increased oxidative stress and neuroinflammation (Scuto et al., 2020)

A new study in Nature Metabolism reveals a previously unappreciated role for selenium-based chemical species as direct electron donors to reduce ubiquinone, thus contributing to redox homeostasis by preventing lipid peroxidation

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