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In p53-mutant GBM, the stronger interaction of mutant p53/NRF2 with p62 enhanced the inhibitory effect of mutant p53 on NRF2 signaling and reversed the classical p62-mediated NRF2 activation pathway, while p62 increased the transcriptional inhibition of SLC7A11 by p53, leading to the reduction of SLC7A11 and acting as a proapoptotic inducer

Naturally produced in the liver, this compound plays crucial roles in detoxification, immune function, and cellular protection against oxidative stress

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Yet, thymosin beta-4 contains additional active regions responsible for broader genomic and enzymatic modulation
