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Vitamin B12 status of patients treated with metformin: a cross-sectional cohort study

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life
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This would be especially true where there is insufficient intrinsic factor produced and/or where the ileum of the small of the intestine is no longer present or able to absorb the vitamin B12/intrinsic factor complex

Vitamin B12 benefits the central nervous system in many important ways
