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[DOI] [PubMed] [Google Scholar] 54.Barb CR, Robertson AS, Barrett JB, Kraeling RR, Houseknecht KL

There was no evidence of associations with other hormones

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As a key coenzyme in mitochondrial energy metabolism, increased NAD enhances mitochondrial oxidative phosphorylation, promotes triglyceride breakdown in adipocytes, and converts fat into energy for the body, thereby reducing adipose tissue accumulation
The competitive relationship between NAM methylation and NAD + recycling suggests that NNMT could impede energy expenditure while promoting lipid accumulation
