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More recently there has been cautious optimism among groups who believe that some studies were perhaps stopped prematurely and that while monotherapies might not be the way forward, combination therapies may hold greater promise [54,57,58,59]

Most patients notice increased energy, better sleep and reduced cravings within the first 1 to 2 weeks

The mechanism of action of melatonin in FM includes various pathways that contribute to its efficacy in the treatment of this disease

Expectations should be realistic: early changes are often about energy and adherence, with body-composition changes building over time

Seeking counseling or therapy: Therapeutic techniques such as cognitive behavioral therapy may help people understand and change their thoughts and behaviors