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8-OHdG 8-hydroxy-2'-deoxyguanosine AMH anti-Mllerian hormone ART assisted reproductive technology ASRM American Society of Reproductive Medicine ATP adenosine triphosphate CAT catalase CCS comprehensive chromosomal screening FISH fluorescence in situ hybridization FF follicular fluid G6PD glucose-6-phosphate dehydrogenase GPx glutathione peroxidase GR glutathione reductase GSH glutathione GST glutathione S-transferase H 2 O 2 hydrogen peroxide ICSI intracytoplasmic sperm injection IL-6 interleukin 6 IVF in vitro fertilization LC L-carnitine MDA malondialdehyde mtDNA mitochondrial DNA NAC N-acetyl cysteine O superoxide anion radical OH hydroxyl radical PF peritoneal fluid PGS preimplantation genetic selection PGT-A preimplantation genetic testing for aneuploidy PN pronucleus ROS reactive oxygen species SOD superoxide dismutase TNF tumor necrosis factor XXO xanthine oxidase

Combination of CPX-351 and gemtuzumab ozogamicin (GO) in relapsed/refractory (R/R) Acute Myeloid Leukemia and post-hypomethylating agent (HMA) failure high-risk myelodysplastic syndrome (HR-MDS)

doi: 10.1158/1078-0432.CCR-14-1088 63 RodonJDienstmannRSerraVTaberneroJ

This review summarizes the most recent evidence concerning biologic and toxicologic effects of acyl glucuronide metabolites of various drugs and discusses their relevance for drug monitoring