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2b, c and Supplementary Fig

Jessica Twumasi-Ankrah and all laboratory technicians at the School of Pharmacy and Noguchi Memorial Institute for Medical Research, University of Ghana, for their technical support

Activated fibroblasts secrete a significant amount of collagen fibers at the periphery of the granuloma, forming a dense capsule that ultimately creates the three-layer pathological structure of classic gout stones: the inner MSU crystal core, the middle chronic inflammatory granuloma zone, and the outer fibrous capsule

But notice what that means its a metabolic balance issue, not a receptor exhaustion issue