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Nature 441, 537541
Rodent studies have identified thyroid C-cell changes
Subject Model Characteristics: The species, age, weight, and overall health status of your research subjects are paramount
NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1
