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Genetic Testing and Molecular Biomarkers

In addition to overexpression, mutations and single nucleotide polymorphisms or SNPs of GRM1 have been identified in multiple cancers, such as prostate (145), colorectal, and lung (146), that led to alterations in receptor activation, intracellular localization, and downstream signaling

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Recommending unapproved treatments undermines this principle and puts patients at unnecessary risk

Preclinical studies consistently demonstrate mechanistic efficacy through modulation of the gutlung axis, while clinical trials provide emerging, though heterogeneous, support for improvements in airway inflammation and symptom control