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Regulatory Lipid Vicinal Diols Counteract the Biological Activity of Epoxy Fatty Acids and Can Act as Biomarkers and Mechanisms for Disease Progression

The Longa method was employed to establish the middle cerebral artery occlusion (MCAO) model in rats 12 : the common carotid artery (CCA), external carotid artery (ECA), and internal carotid artery (ICA) were exposed through a midline incision in the neck

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While this mechanism prevents premature cell death, it simultaneously promotes the accumulation of damaged and dysfunctional cells, which disrupt tissue homeostasis and contribute to the progression of age-related diseases

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