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10.4103/0976-7800.153615 30 DhimanK

Pei R, Mah E, Leonard SW, Traber MG, Bruno RS (2015) -Tocopherol supplementation reduces 5-nitro--tocopherol accumulation by decreasing -tocopherol in young adult smokers
Reduced renal function decreases creatinine clearance and elevates circulating creatinine, a central biomarker of kidney dysfunction

Regarding safety, the overall incidence of AEs was similar between the dose and placebo groups

Lipid peroxides produced by this mechanism have the potential to cause cell death