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HFD-induced changes in GM lead to a heightened prevalence of lipopolysaccharide (LPS)producing bacteria, correlating with elevated risks of hyperglycemia and hyperinsulinemia (132)

Citation: Sikiric, P., Seiwerth, S., Rucman, R., Kolenc, D., Rokotov, D., Brcic, I.,

The latter possibly points to one of the compensatory mechanisms that limits long-term efficacy of bupropion and other weight loss modalities

Still, some early clinical findings hint at potential uses in more specific contexts: Perioperative brain protection: A randomized controlled trial involving 155 liver surgery patients found that ALA reduced oxidative brain injury from anesthesia (sevoflurane) and improved cognitive recovery scores after surgery.31 Neurodegenerative conditions: In a small trial, ALA appeared to slow brain atrophy in patients with secondary progressive multiple sclerosis over a two-year period.32 While promising, this outcome still needs further confirmation