is glutathione conjugation spontaneous transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases Novel insights into conjugation of

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10.1038/s41392-023-01430-7 37 MallatJ.RahmanN.HamedF.HernandezG.FischerM

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In vitro , Sch B suppresses erastin-induced ferroptosis in SH-SY5Y neuroblastoma cells by modulating the GSK3/Nrf2/GPX4 signaling pathway ( in vivo stability, and limited blood-brain barrier permeability ( 2.3 Lipid peroxide accumulation Polyunsaturated fatty acids (PUFAs), which are major constituents of organelle membrane phospholipids, are particularly prone to peroxidation during ferroptosis ( 2+ -driven Fenton reactions, which induce spontaneous oxidation of PUFA-PLs and further accumulation of PUFA-PL-OOHs ( 2+ , ACSL4, MDA, 4-HNE, and -Syn were markedly elevated

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