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Regulation of vascular endotelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo : implication for ovarian follicle angiogenesis

mtDNA is more susceptible to damage (including mutations) than nuclear DNA, likely due to a lack of histones to protect the DNA from damage, the proximity of mtDNA to ROS production, limited DNA repair systems, limited proofreading capacity during replication, and ROS, reactive nitrogen species, and other products produced in the mitochondria that can damage the DNA

The metal-peptide complex can dissociate at elevated temperatures, releasing free copper and reducing efficacy