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The increase of free iron leads to Fenton reaction (Fe 2+ + H 2 O 2 Fe 3+ + OH + OH ), resulting in ROS accumulation and non-enzymatic lipid peroxidation, which leads to the imbalance of antioxidant system and membrane integrity defect, and finally leads to ferroptosis (Forcina and Dixon 2019) (Fig

Subcutaneous MD allows close and extensive monitoring of metabolism with a KD