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PubMed Europe PMC Scholia A pseudo-michaelis quaternary complex in the reverse reaction of a ligase: structure of Escherichia coli B glutathione synthetase complexed with ADP, glutathione, and sulfate at 2.0 A resolution

Shin SY, Lee JM, Lee MS, Koh D, Jung H, Lim Y, et al

It has been shown that once activated, plasmin activates matrix metalloproteinases that allows for macrophage movement through the extracellular matrix [94]

Yet to be determined is whether this complement-inhibiting activity of OspC is mechanistically tied to its antiphagocytic activity (Carrasco et al., 2015)

The switch from an immunologically centered pathogenetic hypothesis to a metabolic-based theory would represent a groundbreaking change in the setting of vitiligo for its therapeutic implications