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the peptide added no detectable benefit over diet and exercise alone

This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety

Most published findings originate from cell-based studies and animal models

William Russell (Director, Mass Spectrometry Facility, Department of Biochemistry and Molecular Biology, UTMB) for his assistance in optimizing and running all LC/MS/MS assessments